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Epigenetics Drives Pancreatic Cancer Metastasis Potentially Reversible

Shared by Radhika Narayanan | 837 114 5 | about 2 years ago

Epigenetics Drives Pancreatic Cancer Metastasis, Potentially Reversible

Improving Manufacturing of Advanced Therapies Is One of Several Initiatives Being Put in Place GEN Interviewed Six Experts to Explore Kinase Assays Sounds of Science Podcast New Immunotherapeutic Strategies Include Bispecific Antibodies Engineered Adenoviruses and Specifically Formulated Vaccines against Cancer A multicenter study led by investigators at Johns Hopkins University just reported on a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer The new data suggests that epigenetic changes control how DNA operates to confer survival advantages on subsets of pancreatic cancer cells Changes in genes regulationnot in the DNA sequence of genes themselveswere the driving force behind successful metastases in our experiments and as far as we know this is the first genome-wide experimental evidence for this phenomenon Even more interestingly the researchers reported evidence that an experimental drugnot approved for human usecan reverse the epigenetic changes to block tumor formation in lab-grown pancreatic cancer cells

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Categories Digital Biology & Genetics Integrated Omics

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