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Strains of E. coli resistant to one antibiotic can protect other bacteria growing nearby

Shared by Radhika Narayanan | 299 120 7 | about 3 years ago

The findings demonstrate that mutualism, a phenomenon in which different species benefit from their interactions with each other, can help bacteria form drug-resistant communities. This is the first experimental demonstration in microbes of a type of mutualism known as cross-protection, which is more commonly seen in larger animals.

The researchers focused on two strains of E. coli, one resistant to ampicillin and the other resistant to chloramphenicol. These bacteria and many others defend themselves from antibiotics by producing enzymes that break down the antibiotics. As a side effect, this also protects cells that don’t produce those enzymes, by removing the antibiotic from the environment.

“Any time that you’re breaking down an antibiotic, there’s this potential for cross-protection,” says Jeff Gore, the Latham Family Career Development Associate Professor of Physics and the senior author of the study, which appears in the Proceedings of the National Academy of Sciences the week of May 16.

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Categories Clinical research Digital chemistry & Pharma IT



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